Hepcinat Plus [ Sofosbuvir & Daclatasvir ] Natco Tablets Uses

Hepcinat Plus  - Sofosbuvir 400 mg & Daclatasvir 60 mg Natco.

Hepcinat plus contains active ingredients of Sofosbuvir 400mg and Daclatasvir 60mg. Hepcinat plus is a film coated tablet in which it composed of white to yellow colour solid and freely soluble in methanol and water. Hepcinat plus is a oval shape white colour tablet.


Patients with genotype 1 or 4 without cirrhosis by Hepcinat plus is for 12 to 24 weeks prolongation of therapy before NS3/4A protease inhibitor
Patients with genotype 1 or 4 with compensated cirrhosis by Hepcinat plus for 24 weeks short periods to 12 weeks which provided for previously untreated patients with cirrhosis and low baseline viral load.
Patients with genotype 3 with compensated cirrhosis and experienced treatment by Hepcinat plus + ribavirin for 24 weeks.


Hepcinat plus consist of Sofosbuvir 400mg is an direct-acting antiviral drug which acts against the hepatitis C virus. It is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which involves for viral poliferation. Sofosbuvir (Hepcinat plus ) is a prodrug of nucleotide polymerase inhibitor which go through intracellular metabolism to form the active pharmacologically uridine analog triphosphate (GS-461203), that may fused into HCV RNA by the NS5B polymerase and process as a chain terminator.
Daclatasvir is also an antiviral regimen which involves inhibitor of nonstructural protein 5A (NS5A), and It acts an multifunctional protein that is an fundamental component of the HCV multiplication complex. Daclatasvir prevents the both viral RNA multiplication and virion accumulation
Hepcinat Plus Uses


Hepcinat plus composed of two drug combination of sofosbuvir 400mg and Daclatasvir 60mg which is used for the treatment of chronic Hepcinat C virus (HCV) genotype 3 infection in patient. 


common side effects:
  • Anemia
  • Loss of appetite
  • Depression
  • Anxiety
  • Insomnia
  • Dizziness, migraine
  • Athralgia, myalgia

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Hepcinat Plus Natco

Hepcinat Plus [ Daclatasvir 60 mg / Sofosbuvir 400 mg ] Natco :

Hepcinat Plus [ Sofosbuvir + Daclatasvir ]  is two prime components which has anti-viral property opposing to hepatitis C viral infection. Both the components are used as single dose, available in the strength of 400mg Sofosbuvir and 60mg Daclatasvir.

Usually Daclatasvir is not used alone; it should be combining with sofosbuvir and plays a vital role in hepatitis C viral infection
Hepcinat Plus [ Sofosbuvir and Daclatasvir ]  should be combined with other anti-viral medicine like ribavirin used in the condition such as decompensated cirrhosis
Both Hepcinat Plus [ Sofosbuvir and Daclatasvir ] are non structural protein inhibitor, which involved in HCV infections by inhibiting the NS5B & NS5A. The Viral RNA polymerase enzyme is essential for viral replication, which get prohibits by sofosbuvir

This fixed dose combination majorly indicated in hepatitis C infection related to genotype III
The main disadvantage of sofosbuvir and Daclatasvir is;
In hepatitis C genotype III infected patients, the maintained virological response rate are become shortened, while using Daclatasvir combined with sofosbuvir for 12 weeks

Hepcinat Plus  tablets are anti-viral medication, containing two most predominant ingredients such as Sofosbuvir and Daclatasvir.

Hepcinat Plus  tablets are single dose therapy, it is a prescription medicine used by the patients only under the knowledge of medical practitioner who are well practiced.
Hepcinat Plus  is not used alone, for better action it should be combined with Hepcinat Plus .
In some condition Hepcinat Plus  is combined with ribavirin, an anti-viral medicine used in decompensated (Child Pugh B or C) cirrhosis.

Brand name: Hepcinat Plus

Active components: Hepcinat PlusDaclatasvir  60 mg /   Sofosbuvir  400 mg ]
Strength of the components: 400mg & 60mg respectively
Mfg: Natco 
Package: 28 tablets in a container
Category: Anti-viral drug

Hepcinat Plus natco
Hepcinat Plus 

Hepcinat Plus Side Effects  :

The most common side effects occurred during the therapy;
Elevation of lipase
Cardiac problems like symptomatic bradycardia
Loss of appetite
Influenza like symptoms


Hepcinat Plus Storage and handling :
The storage condition of Hepcinat Plus should be stored at room temperature below 30oC (86oF) & 20oC and 25oC (68oF and 77oF) respectively.
Container should be keep away from heat, light and moisture.

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Velasof 400 мг / 100 мг Таблетка используется для лечения хронической инфекции вируса гепатита С (HCV).

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Hepcvel Uses :

  • Hepcvel tablets is used to tretment of Hepatitis C.
  • Is a  combination of Sofosbuvir 400mg  and Velpatasvir 100mg
  • To Control the HCV infection in your body.

Hepcvel Cipla Tablet indication :

  • Sofosbuvir 400 mg & Velpatasvir 100 mg s used alone or with ribavirin to treat chronic hepatitis C infection.
  • Sofosbuvir 400mg  is in a class of antiviral medications called nucleotide HEP C Virus.
  • Velpatasvir100mg  is in a class of antiviral medications called HCV. 
  • Sofosbuvir and Velpatasvir  works by stopping the virus that causes Hepatitis C  Virus from spreading inside the Body.

HEPCVEL Dosage and Administration :

  • Test all patients for evidence of current or prior HBV and HCV infection by measuring hepatitis B surface antigen and hepatitis B core antibody (anti HBc) before initiating HCV treatment with HEPCVEL Tablets.
  • HEPCVEL Tablets are a two drug containing  Sofosbuvir 400mg  and Velpatasvir100mg in a single tablet.
  • The recommended dosage of HEPCVEL Tablets is one tablet taken orally once daily with or without food.
Hepcvel Cipla Tablets

HEPCVEL Contraindications :

  • Sofosbuvir 400mg  Velpatasvir 100mg  FDC and ribavirin combination regimen is contraindicated in patients for whom ribavirin is contraindicated. Refer to the ribavirin prescribing information for a list of contraindications for ribavirin.
HEPCVEL Warnings and Precautions :

Sofosbuvir 400mg and Velpatasvir 100mg are substrates of drug transporters P-gp and BCRP while GS-331007. In vitro, slow metabolic turnover of velpatasvir by CYP2B6, CYP2C8, and CYP3A4 was observed.


  • Headache, tired feeling; nausea, diarrhea; or sleep problems (insomnia).

  • Brand Name : Hepcvel
  • Content : Sofosbuvir and Velpatasvir
  • Packing : Pack of 28 tablets
  • Strength :  Velpatasvir100mg and Sofosbuvir 400mg
  • Manufactured by : CIPLA Ltd.
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    Hepcinat Plus [ Sofosbuvir & Daclatasvir ] Natco Tablets Uses

    Hepcinat Plus   - Sofosbuvir 400 mg & Daclatasvir 60 mg Natco. Hepcinat plus contains active ingredients of Sofosbuvir 400mg and Dacl...